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Mechanism of hepatic microsomal oxidation of 11-hydroxy-Δ-8-tetrahydrocannabinol to 11-oxo-Δ8-tetrahydrocannabinol. Evidence for hydration of the aldehyde formedWATANABE, K; MATSUNAGA, T; NARIMATSU, S et al.Journal of pharmacobio-dynamics. 1992, Vol 15, Num 6, pp 311-317, issn 0386-846XConference Paper

Structure elucidation and conformational properties of synthetic cannabinoids (-)-2-(6a, 7,10, 10a-tetrahydro-6,6,9-trimethyl- 1-hydroxy-6H-dibenzo [b, d]pyranyl)-2-hexyl-1,3-dithiolane and its methylated analogMAVROMOUSTAKOS, T; THEODOROPOULOU, E; ZERVOU, M et al.Journal of pharmaceutical and biomedical analysis. 1999, Vol 18, Num 6, pp 947-956, issn 0731-7085Article

Topography of tetrahydrocannabinol in model membranes using neutron diffractionMARTEL, P; MAKRIYANNIS, A; MAVROMOUSTAKOS, T et al.Biochimica et biophysica acta. Biomembranes. 1993, Vol 1151, Num 1, pp 51-58, issn 0005-2736Article

Small angle X-ray diffraction studies of (-)-Δ8-tetrahydrocannabinol and its O-methyl analog in membranesDE-PING YANG; MAVROMOUSTAKOS, T; MAKRIYANNIS, A et al.Life sciences (1973). 1993, Vol 53, Num 7, pp PL-117, issn 0024-3205, -PL-122Article

CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Δ8-tetrahydrocannabinol to 7-oxo-Δ8-tetrahydrocannabinol in human liver microsomesMATSUNAGA, Tamihide; KISHI, Nobuyuki; HIGUCHI, Shinsuke et al.Drug metabolism and disposition. 2000, Vol 28, Num 11, pp 1291-1296, issn 0090-9556Article

Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMRJIANXIN GUO; PAVLOPOULOS, Spiro; XIAOYU TIAN et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 23, pp 4838-4846, issn 0022-2623, 9 p.Article

A new cannabinoid, Δ6-tetrahydrocannabinol 2-O-β-D-glucopyranoside, biotransformed by plant tissueTANAKA, H; TAKAHASHI, R; MORIMOTO, S et al.Journal of natural products (Print). 1997, Vol 60, Num 2, pp 168-170, issn 0163-3864Article

Fatty acid conjugates of 11-hydroxy-Δ8-tetrahydrocannabinol : In vitro formation and hydrolysis by the mouse pancreasKAYANO, Y; WATANABE, K; MATSUNAGA, T et al.Research communications in alcohol and substances of abuse. 1996, Vol 17, Num 3-4, pp 143-149, issn 1080-8388Article

Synthesis and pharmacological effects of a chimera derivative of tetrahydrocannabinol and phenobarbital, tetrahydro-6,6-dimethyl-9-[5'-phenyl-2',4',6'-(1'H,3'H,5'H)-pyrimidinetrionyl]-3-pentyl-6H-dibenzo[b,d]pyran-ol (TP)TATEOKA, Y; USAMI, N; WATANABE, K et al.Research communications in alcohol and substances of abuse. 1996, Vol 17, Num 3-4, pp 151-163, issn 1080-8388Article

Characterization of a region of steric interference at the cannibinoid receptor using the active analog approachREGGIO, P. H; PANU, A. M; MILES, S et al.Journal of medicinal chemistry (Print). 1993, Vol 36, Num 12, pp 1761-1771, issn 0022-2623Article

Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-Δ8-tetrahydrocannabinol to Δ8-tetrahydrocannabinol-11-oic acidWATANABE, K; MATSUNAGA, T; NARIMATSU, S et al.Biochemical pharmacology. 1991, Vol 42, Num 6, pp 1255-1259, issn 0006-2952Article

In vivo metabolism of the ethyl homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouseBROWN, N. K; HARVEY, D. J.Biological mass spectrometry. 1991, Vol 20, Num 5, pp 324-328Article

Pharmacological specificity of the discriminative stimulus effects of Δ9-tetrahydrocannabinol in rhesus monkeysWILEY, J. L; HUFFMAN, J. W; BALSTER, R. L et al.Drug and alcohol dependence. 1995, Vol 40, Num 1, pp 81-86, issn 0376-8716Article

Localization of liphophilic molecules penetrating rat skin in vivo by quantitative autoradiographyFABIN, B; TOUITOU, E.International journal of pharmaceutics. 1991, Vol 74, Num 1, pp 59-65, issn 0378-5173Article

Effects of low doses of alcohol on delta-9-tetrahydrocannabinol's effects in pregnant ratsABEL, E. L; SUBRAMANIAN, M. G.Life sciences (1973). 1990, Vol 47, Num 18, pp 1677-1682, issn 0024-3205, 6 p.Article

Pharmacological evaluation of water soluble cannabinoids and related analogsCOMPTON, D. R; MARTIN, B. R.Life sciences (1973). 1990, Vol 46, Num 22, pp 1575-1585, issn 0024-3205, 11 p.Article

Toxicokinetics of drugs of abuse : Current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeineMAURER, Hans H; SAUER, Christoph; THEOBALD, Denis S et al.Therapeutic drug monitoring. 2006, Vol 28, Num 3, pp 447-453, issn 0163-4356, 7 p.Article

Characterization of microsomal alcohol oxygenase catalyzing the oxidation of 7-hydroxy-Δ8-tetrahydrocannabinol to 7-oxo-Δ8-tetrahydrocannabinol in rat liverMATSUNAGA, T; SHIBAYAMA, K; HIGUCHI, S et al.Biological & pharmaceutical bulletin. 2000, Vol 23, Num 1, pp 43-46, issn 0918-6158Article

Dimethylheptyl-THC-11 OIC acid : A nonpsychoactive antiinflammatory agent with a cannabinoid template structureZURIER, R. B; ROSSETTI, R. G; LANE, J. H et al.Arthritis and rheumatism. 1998, Vol 41, Num 1, pp 163-170, issn 0004-3591Article

Mouse hepatic microsomal enzyme that catalyzes oxidation of 11-oxo-Δ8-tetrahydrocannabinol to Δ8-tetrahydrocannabinol-11-oic acidWATANABE, K; HIRAHASHI, N; NARIMATSU, S et al.Drug metabolism and disposition. 1991, Vol 19, Num 1, pp 218-221, issn 0090-9556, 4 p.Article

Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in miceWATANABE, K; KIJIMA, T; NARIMATSU, S et al.Chemical and pharmaceutical bulletin. 1990, Vol 38, Num 8, pp 2317-2319, issn 0009-2363, 3 p.Article

The search for selective ligands for the CB2 receptorHUFFMAN, J. W.Current pharmaceutical design. 2000, Vol 6, Num 13, pp 1323-1337, issn 1381-6128Article

Isomerization of delta-9-THC to delta-8-THC when tested as trifluoroacetyl-, pentafluoropropionyl-, or heptafluorobutyryl-derivativesHOLLER, Justin M; SMITH, Michael L; PAUL, Shom N et al.Journal of mass spectrometry. 2008, Vol 43, Num 5, pp 674-679, issn 1076-5174, 6 p.Article

Major cytochrome P450 enzyme responsible for oxidation of secondary alcohols to the corresponding ketones in mouse hepatic microsomes: Oxidation of 7-hydroxy-Δ8-tetrahydrocannabinol to 7-oxo-Δ8-tetrahydrocannabinolMATSUNAGA, T; KISHI, N; TANAKA, H et al.Drug metabolism and disposition. 1998, Vol 26, Num 10, pp 1045-1047, issn 0090-9556Article

Evaluation of a point-of-care testing product for drugs of abuse ; testing site is a key variableKRANZLER, H. R; STONE, J; MCLAUGHLIN, L et al.Drug and alcohol dependence. 1995, Vol 40, Num 1, pp 55-62, issn 0376-8716Article

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